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Article

A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1.

Nature communications - 29 Apr 2024

Rybak Jeffrey M, Xie Jinhong, Martin-Vicente Adela, Guruceaga Xabier, Thorn Harrison I, Nywening Ashley V, Ge Wenbo, Souza Ana C O, Shetty Amol C, McCracken Carrie, Bruno Vincent M, Parker Josie E, Kelly Steven L, Snell Hannah M, Cuomo Christina A, Rogers P David, Fortwendel Jarrod R

Abstract excerpt

Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific inhibition of a cytochrome P450 14-α-sterol demethylase enzyme, Cyp51A/B, resulting in depletion of cellular ergosterol. Here, we uncover a clinically relevant secondary mechanism of action...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38684680
DOI: 10.1038/s41467-024-48029-2
PMCID: PMC11059170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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