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A screen to identify antifungal antagonists reveals a variety of pharmacotherapies induce echinocandin tolerance in <i>Candida albicans</i>

2025-02-21

Abstract excerpt

Through screening a comprehensive collection of drugs approved for human use, we identified over 20 that oppose the antifungal activity of the echinocandins upon the infectious yeast, Candida albicans . More detailed evaluation of five such drugs, including the atypical antipsychotic aripiprazole and the tyrosine kinase inhibitor ponatinib, indicated they promote C. albicans survival following exposure to the ec...

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Identifiers and source

Literature Corpus work
257c0674-0427-5991-81f5-83d80726b6f3
DOI
10.1101/2025.02.18.638903
Open publication

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