Type I IFN family members: similarity, differences and interaction.

doi:10.1016/j.cytogfr.2014.10.011

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Article

Type I IFN family members: similarity, differences and interaction.

Cytokine & growth factor reviews - 1 Apr 2015

Capobianchi Maria Rosaria, Uleri Elena, Caglioti Claudia, Dolei Antonina

Abstract excerpt

Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I-III) based on structural features, receptor usage, cellular source and biological activities. The action of IFNs is mediated by a complex, partially overlapping, transcriptional program initiated by the interaction with specific receptors. Genetic diversity, with...

Topics

Antiviral Agents
Cell Differentiation
Cell Proliferation
Genetic Variation
Humans
Interferon Type I
Interferon-gamma
Interferons
Receptor, Interferon alpha-beta
Signal Transduction
Transcriptional Activation
Virus Diseases

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Identifiers

PMID: 25466633
DOI: 10.1016/j.cytogfr.2014.10.011
PMCID: PMC7108279

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