Article

Profiling transcription factor sub-networks in type I interferon signaling and in response to SARS-CoV-2 infection

2021-01-25

Abstract excerpt

Type I interferons (IFN α/β) play a central role in innate immunity to respiratory viruses, including coronaviruses. Genetic defects in type I interferon signaling were reported in a significant proportion of critically ill COVID-19 patients. Extensive studies on interferon-induced intracellular signal transduction pathways led to the elucidation of the Jak-Stat pathway. Furthermore, advances in gene expression pr...

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Literature Corpus work: eb3d0a43-92e3-5996-9f55-0ff9699c34b5
DOI: 10.1101/2021.01.25.428122

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