Article

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

2020-10-31

Abstract excerpt

While inhibition of T cell co-inhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. Type 1 interferon (IFN-I) modulates T cell immunity in viral infection, autoimmunity, and cancer, and may facilitate induction of T cell exhaustion in chronic viral infection 1,2 . Here we show that IFN-I regulates co-inhibitory receptors expres...

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Literature Corpus work: 203f5f31-9233-5f34-8c02-4da77e2f51d7
DOI: 10.1101/2020.10.30.362947

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