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Article

Dynamic rewiring of the human interactome by interferon signaling

15 Jun 2020

Abstract excerpt

BACKGROUND: The type I interferon (IFN) response is an ancient pathway that protects cells against viral pathogens by inducing the transcription of hundreds of IFN-stimulated genes. Comprehensive catalogs of IFN-stimulated genes have been established across species and cell types by transcriptomic and biochemical approaches, but their antiviral mechanisms remain incompletely characterized. Here, we apply a...

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PMID: 32539747
DOI: 10.1186/s13059-020-02050-y

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