Article

Topological analysis of single-cell data reveals shared glial landscape of macular degeneration and neurodegenerative diseases

2021-01-20

Abstract excerpt

1 <h4>One Sentence Summary</h4> A novel topological machine learning approach applied to single-nucleus RNA sequencing from human retinas with age-related macular degeneration identifies interacting disease phase-specific glial activation states shared with Alzheimer’s disease and multiple sclerosis. 2 Neurodegeneration occurs in a wide range of diseases, including age-related macular degeneration (AMD), Alzheime...

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Literature Corpus work: b065f2b7-26eb-51f9-815a-08dc31b0ef55
DOI: 10.1101/2021.01.19.427286

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