Article

Single-nucleus RNA velocity reveals synaptic and cell-cycle dysregulations missed by gene expression in neuropathologic Alzheimer disease

2022-11-01

Abstract excerpt

To characterize the dynamic genetic and cellular differences in AD neuropathology, we apply the novel concept of RNA velocity to the study of single-nucleus RNA from the cortex of 60 subjects with varied levels of AD pathology. RNA velocity captures the rate of change of gene expression by comparing intronic and exonic sequence counts. We performed differential analyses to find the significant genes driving both c...

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Literature Corpus work: 280899d6-dfd1-5f5f-bd22-07d1b44deb23
DOI: 10.1101/2022.10.31.22281759

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