Article

Single-cell analysis of the human retina reveals stage-linked microglial states and neural-immune circuit rewiring in diabetic retinopathy

2025-02-08

Abstract excerpt

Diabetic retinopathy (DR) is a major cause of vision loss worldwide. Here, we conduct single-cell RNA sequencing of twenty human retina samples (from living and post-mortem donors) across non-diabetic, diabetic, and DR states to create a comprehensive transcriptomic atlas. We identify two stable microglial populations—homeostatic and inflammatory—that exist along a functional continuum, plus a neutrophil cluster w...

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Literature Corpus work: 5cd8ea8b-89e0-5a96-85cc-c9893671a318
DOI: 10.1101/2025.02.07.637193

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