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A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration

18 Apr 2023

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200 million people worldwide. To identify genes that could be targeted for treatment, we created a molecular atlas at different stages of AMD. Our resource is comprised of RNA sequencing (RNA-seq) and DNA methylation microarrays from bulk macular retinal pigment epithelium (RPE)/choroid of clinically phenotyped normal and AMD donor...

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PMID: 37388919
DOI: 10.1016/j.xgen.2023.100302

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