Article

Distributed Clonal Deletion Prevents Autoimmune Disease Progression

2026-05-16

Abstract excerpt

Self-reactive B cells are generated during normal development and can acquire increased pathogenicity through activation-induced cytidine deaminase (AID)-mediated diversification following activation. Clonal deletion is thought to eliminate these cells, yet how deletion is distributed across developmental and activation stages to prevent autoimmune disease remains unclear. Here, we show that clonal deletion is enf...

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Literature Corpus work: 6bea5a3e-dc9a-5a42-9a96-6e484c1626d4
DOI: 10.64898/2026.05.12.724341

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