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Article

A cholinergic checkpoint controls autoantibody selection via somatic hypermutation in lupus germinal centers.

Cellular & molecular immunology - 1 Aug 2026

Li Jin, Lai Yimei, Zou Huijin, Qian Yichao, Ruan Xinyuan, Zhuang Lili, Lin Zhangmei, Wang Yumeng, Yang Niansheng, Wang Shuyi, Zhang Hui

Abstract excerpt

Systemic lupus erythematosus (SLE) pathogenesis involves the dysregulated production of mutated, high-affinity autoantibodies, a process primarily orchestrated within germinal centers (GCs). However, the precise regulatory mechanisms governing the GC-mediated generation of autoantibodies in SLE remain elusive. In lupus-prone NZM2328 mice, we observed progressive accumulation of immunoglobulin heavy chain (Igh)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42332094
DOI: 10.1038/s41423-026-01444-5
PMCID: PMC13424102

Genes

GC
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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