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Article

Follicular helper T cells are required for systemic autoimmunity.

The Journal of experimental medicine - 16 Mar 2009

Linterman Michelle A, Rigby Robert J, Wong Raphael K, Yu Di, Brink Robert, Cannons Jennifer L, Schwartzberg Pamela L, Cook Matthew C, Walters Giles D, Vinuesa Carola G

Abstract excerpt

Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection of GC B cells, caused by either failure of negative selection or enhanced positive selection by follicular helper T (T(FH)) cells, is a plausible explanation for these autoantibodies. Mice homozygous for the san...

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Share to Antigens, Differentiation, T-Lymphocyte
Share to CD28 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germinal Center

Share to Inducible T-Cell Co-Stimulator Protein

Share to Interleukin-21

Share to Lymphocyte Subsets

Share to Proto-Oncogene Proteins c-bcl-6

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 19221396
DOI: 10.1084/jem.20081886
PMCID: PMC2699132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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