Murine lupus: pathogenic mechanisms and genetic origins.

Abstract excerpt

Research in several murine models of lupus, reinforced with patient studies, has served to identify key events leading to lupus nephritis. Among these, anti-nuclear antibody (ANA) induced end-organ damage, production of such ANAs by intrinsically hyperactive B-cells, and antigen-specific, cognate T-cell help have been well documented. Though studies in parallel fields of immunology have uncovered a plethora of...

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