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Ubiquitin E3 ligases in cancer: somatic mutation and amplification

2 May 2023

Abstract excerpt

Defects in DNA double-strand break (DSB) repair signaling permit cancer cells to accumulate genomic alterations that confer their aggressive phenotype. Nevertheless, tumors depend on residual DNA repair abilities to survive the DNA damage induced by genotoxic stress. This is why only isolated DNA repair signaling is inactivated in cancer cells. DNA DSB repair signaling contributes to general mechanism for various...

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PMID: 37081755
DOI: 10.5483/bmbrep.2023-0037

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