Article

Cosmic signature SBS39 is associated with homologous recombination deficiency

2024-10-27

Abstract excerpt

<h4>ABSTRACT</h4> Cosmic single-base-substitution mutational signature 3 (SBS3) is associated with hereditary and somatic mutations in genes involved in homologous recombination deficiency (HRD) and predicts response to PARPi. The COSMIC database was updated from 30 SBS signatures in version 2.0 (V2.0) to 86 SBS signatures in Version 3.4 (V3.4). We found that SBS3 in V3.4 was poorly associated and SBS39 was stron...

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Literature Corpus work: bd1d5ebc-ad0a-5c58-8427-089af8a826a6
DOI: 10.1101/2024.10.23.24316019

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