Article

Loss of HMCES is synthetic lethal with APOBEC activity in cancer cells

2021-02-06

Abstract excerpt

Analysis of cancer mutagenic signatures provides information about the origin of mutations and can inform the use of clinical therapies, including immunotherapy. In particular, APOBEC3A (A3A) has emerged as a major driver of mutagenesis in cancer cells and its expression results in DNA damage and susceptibility to treatment with inhibitors of the ATR and CHK1 checkpoint kinases. Here we report the implementation o...

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Literature Corpus work: 4285e23c-48a2-52b3-bd4f-be8af834e372
DOI: 10.1101/2021.02.05.429803

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