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The Link Between Human Alkyladenine DNA Glycosylase and Cancer Development

7 Aug 2025

Abstract excerpt

Alkyladenine DNA glycosylase (AAG) is a critical enzyme in the base excision repair (BER) pathway, responsible for removing a broad spectrum of alkylated DNA lesions. While AAG maintains genomic stability, dysregulated activity has been implicated in cancer development, drug resistance, and neurodegenerative diseases. This review synthesizes the current knowledge on AAG's structure, catalytic mechanism, and...

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PMID: 40806775
DOI: 10.3390/ijms26157647

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