Article

A germline KDM3C polymorphism impairs DNA repair and sensitizes to chemoradiotherapy

2026-08-31

Abstract excerpt

Chemoradiotherapy (CRT) is the standard-of-care therapy for many solid malignancies, yet predictive biomarkers of treatment response remain limited. We identified a germline single nucleotide polymorphism (SNP) in an intrinsically disordered region of the lysine demethylase KDM3C/JMJD1C (p.S464T) that is associated with CRT outcomes in locally advanced rectal cancers (LARC) and head and neck squamous cell carcinom...

Identifiers and source

Literature Corpus work: 7d1b2341-a157-56ad-b07a-a8bdc6df0675
DOI: 10.64898/2026.08.26.26360896

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