Article

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies

2020-03-16

Abstract excerpt

Glioblastomas are the most lethal tumors affecting the central nervous system in adults. Simple and inexpensive syngeneic in vivo models that closely mirror human glioblastoma, including interactions between tumor and immune cells, are urgently needed for deciphering glioma biology and developing more effective treatments. Here, we generated glioblastoma cell lines by repeated in-vivo passaging of cells isolated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0fb0eed6-f115-500f-acf4-fe4442f6bfd3
DOI: 10.1101/2020.03.16.993196

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studiesDOI 10.1101/2020.03.16.993196Read

Exploring the immune environment of glioblastoma through single-cell RNA sequencing in humanized mouse modelsSemantic proximity Read

A syngeneic glioblastoma mouse model with mesenchymal hallmarks.Semantic proximity Read

In vivo mouse models for adult brain tumors: Exploring tumorigenesis and advancing immunotherapy developmentSemantic proximity Read

Molecular biology of the deadliest cancer – glioblastoma: what do we know?Semantic proximity Read

Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade.Semantic proximity Read

Single-cell dissection of the genotype-immunophenotype relationship in glioblastoma.Semantic proximity Read

Glioblastoma preclinical models: Strengths and weaknessesSemantic proximity Read

Immune landscape of a genetically-engineered murine model of glioma relative to human glioma by single-cell sequencingSemantic proximity Read

Glioblastoma Stem Cells at the Nexus of Tumor Heterogeneity, Immune Evasion, and Therapeutic ResistanceSemantic proximity Read

Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse modelsSemantic proximity Read

Modeling Glioma Intratumoral Heterogeneity with Primary Human Neural Stem and Progenitor CellsSemantic proximity Read

Immune landscape of a genetically engineered murine model of glioma compared with human gliomaSemantic proximity Read