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Article

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.

Nature methods - 1 Aug 2008

Breslow David K, Cameron Dale M, Collins Sean R, Schuldiner Maya, Stewart-Ornstein Jacob, Newman Heather W, Braun Sigurd, Madhani Hiten D, Krogan Nevan J, Weissman Jonathan S

Abstract excerpt

Functional genomic studies in Saccharomyces cerevisiae have contributed enormously to our understanding of cellular processes. Their full potential, however, has been hampered by the limited availability of reagents to systematically study essential genes and the inability to quantify the small effects of most gene deletions on growth. Here we describe the construction of a library of hypomorphic alleles of...

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Identifiers

PMID: 18622397
DOI: 10.1038/nmeth.1234
PMCID: PMC2756093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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