Article

Extracellular vesicle α-synuclein seeds drive divergent phenoconversion from iRBD to Parkinsonism

2026-01-09

Abstract excerpt

<title>Abstract</title> <p>Idiopathic rapid eye movement (REM) sleep behaviour disorder (iRBD) is a prodromal ɑ-synucleinopathy that often precedes Parkinson’s disease (PD) or multiple system atrophy (MSA), but the determinants of divergent conversion are unknown. We isolated neuronal extracellular vesicles (NEV) from PD plasma and oligodendroglial extracellular vesicles (OEV) from MSA plasma and found that they...

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Literature Corpus work: 28706856-f2ec-5dbb-8623-f3d685a29ed0
DOI: 10.21203/rs.3.rs-8466772/v1

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