Article

Loss of Fragile X Protein Impacts α-Synuclein Homeostasis via Insulin-Degrading Enzyme in Parkinson’s Disease

2026-07-20

Abstract excerpt

<title>Abstract</title> <p> Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra and the pathological accumulation of α-synuclein (αSyn) aggregates to Lewy bodies (LBs). While LB formation is a hallmark of PD, the molecular mechanisms underlying αSyn aggregation remain incompletely defined. We recently identified an early loss of fragile X mental r...

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Literature Corpus work: dc30a76f-d6fb-518b-8b33-0cede52f20f1
DOI: 10.21203/rs.3.rs-10296980/v1

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