Article
Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms.
Translational neurodegeneration - 10 Mar 2026
Dautan Daniel, Paslawski Wojciech, Montejo Sergio G, Doyon Daniel C, Brioschi Valentina I, Marongiu Roberta, Kaplitt Michael G, Chen Rong, Dawson Valina L, Zhang Xiaoqun, Dawson Ted M, Svenningsson Per
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by both motor and non-motor symptoms. Although non-motor features such as gastrointestinal and sleep disturbances often precede motor impairments and are critical to PD pathogenesis, the mechanisms underlying their onset and progression remain insufficiently characterized. METHODS: To investigate the sequential development of...
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