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Article

Development of a clinical polygenic risk score assay and reporting workflow.

Nature medicine - 1 May 2022

Hao Limin, Kraft Peter, Berriz Gabriel F, Hynes Elizabeth D, Koch Christopher, Korategere V Kumar Prathik, Parpattedar Shruti S, Steeves Marcie, Yu Wanfeng, Antwi Ashley A, Brunette Charles A, Danowski Morgan, Gala Manish K, Green Robert C, Jones Natalie E, Lewis Anna C F, Lubitz Steven A, Natarajan Pradeep, Vassy Jason L, Lebo Matthew S

Abstract excerpt

Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid assays, interpretation for individual patients, and the development of clinical workflows and resources to support their use in patient care. For the ongoing Veterans Affairs Genomic Medicine at Veterans Affairs (GenoVA) Study we developed a clinical...

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Identifiers

PMID: 35437332
DOI: 10.1038/s41591-022-01767-6
PMCID: PMC9117136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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