Article

Replication Protein A1 is essential for DNA damage repair during mammalian oogenesis

2023-07-04

Abstract excerpt

Persistence of unrepaired DNA damage in oocytes is detrimental and may cause genetic aberrations, miscarriage, and infertility. RPA, an ssDNA-binding complex, is essential for various DNA-related processes. Here we report that RPA plays a novel role in DNA damage repair during postnatal oocyte development after meiotic recombination. To investigate the role of RPA during oogenesis, we inactivated RPA1 (replication...

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Literature Corpus work: afc3fed9-b081-5255-bf63-c21a91f8979d
DOI: 10.1101/2023.07.04.547725

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