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The DNA Damage Response in Fully Grown Mammalian Oocytes

24 Feb 2022

Abstract excerpt

DNA damage in cells can occur physiologically or may be induced by exogenous factors. Genotoxic damage may cause cancer, ageing, serious developmental diseases and anomalies. If the damage occurs in the germline, it can potentially lead to infertility or chromosomal and genetic aberrations in the developing embryo. Mammalian oocytes, the female germ cells, are produced before birth, remaining arrested at the...

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PMID: 35269420
DOI: 10.3390/cells11050798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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