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Article

DNA damage and repair in the female germline: contributions to ART

6 Nov 2018

Abstract excerpt

BACKGROUND: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. If...

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PMID: 30541031
DOI: 10.1093/humupd/dmy040

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