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Dual functions for the ssDNA-binding protein RPA in meiotic recombination

4 Feb 2019

Abstract excerpt

Meiotic recombination permits exchange of genetic material between homologous chromosomes.The replication protein A (RPA) complex, the predominant ssDNA-binding complex, is required for nearly all aspects of DNA metabolism, but its role in mammalian meiotic recombination remains unknown due to the embryonic lethality of RPA mutant mice.RPA is a heterotrimer of RPA1, RPA2, and RPA3.We find that loss of RPA1, the...

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PMID: 30716097
DOI: 10.1371/journal.pgen.1007952

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