Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes.

PloS one - 1 Jan 2016

Challa Anil K, Boitet Evan R, Turner Ashley N, Johnson Larry W, Kennedy Daniel, Downs Ethan R, Hymel Katherine M, Gross Alecia K, Kesterson Robert A

Abstract excerpt

Tyrosinase is a key enzyme in melanin biosynthesis. Mutations in the gene encoding tyrosinase (Tyr) cause oculocutaneous albinism (OCA1) in humans. Alleles of the Tyr gene have been useful in studying pigment biology and coat color formation. Over 100 different Tyr alleles have been reported in mice, of which ≈24% are spontaneous mutations, ≈60% are radiation-induced, and the remaining alleles were obtained by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Clustered Regularly Interspaced Short Palindromic Repeats

Share to Hair Color

Share to Monophenol Monooxygenase

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 27224051
DOI: 10.1371/journal.pone.0155812
PMCID: PMC4880214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes.PMID 27224051Read ↗

Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes.Semantic proximity Read ↗

The structure and function of the mouse tyrosinase locus.Semantic proximity Read ↗

Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system.Semantic proximity Read ↗

Genome editing of a low-penetrance albinism-associated variant in TYR in patient-derived pluripotent stem cellsSemantic proximity Read ↗

The tyrosinase gene and oculocutaneous albinism type 1 (OCA1): A model for understanding the molecular biology of melanin formation.Semantic proximity Read ↗

CRISPR/Cas9-mediated mutation of tyrosinase (Tyr) 3' UTR induce graying in rabbit.Semantic proximity Read ↗

Identification and characterization of two novel noncoding tyrosinase (TYR) gene variants leading to oculocutaneous albinism type 1.Semantic proximity Read ↗

Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing.Semantic proximity Read ↗

Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system.Semantic proximity Read ↗

The Tyr (albino) locus of the laboratory mouse.Semantic proximity Read ↗

CRISPR/Cas9-mediated precise genome modification by a long ssDNA template in zebrafish.Semantic proximity Read ↗

Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.