Article

Resolving the molecular niche of pulmonary fibrosis using cryopreserved human precision cut lung slices

2025-04-26

Abstract excerpt

<h4>Background and methods</h4> Pulmonary fibrosis (PF) manifests locally and heterogeneously in the diseased lung. To uncover mechanistic underpinnings, we have utilized cryopreserved fibrotic human precision-cut lung slices (PCLS), and using single-cell spatial transcriptomics, mapped and interpreted the transcriptomic regulation of effector cell types/states. <h4>Results</h4> Cryopreserved-thawed fibrotic hum...

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Literature Corpus work: afb5ae5c-2fcf-5eba-b91a-e90fd8510e02
DOI: 10.1101/2025.04.22.649643

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