Article

Spatial multiomic profiling reveals distinct fibrotic epithelial niches in idiopathic pulmonary fibrosis

2024-12-12

Abstract excerpt

<h4>Background</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease characterised by excessive extracellular matrix deposition within the lung. Recent advances in single-cell RNA sequencing have identified distinct fibrotic populations, yet their origins and spatial relationships remain incompletely understood. <h4>Methods</h4> Using spatial transcriptomics and Hyperion imaging mass cytometry...

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Literature Corpus work: 30536f18-5ad9-590a-a5f3-1f03c48ba888
DOI: 10.1101/2024.12.10.627749

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