Article
Translational mapping of spatially resolved transcriptomes in human and mouse pulmonary fibrosis
2023-12-21
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and limited treatment options. Efforts to identify effective treatments are thwarted by limited understanding of IPF pathogenesis and poor translatability of available preclinical models. To address these limitations, we generated spatially resolved transcriptome maps of human IPF and bleomycin-induced mouse lung fibrosis. We unc...
Topics
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- Extracellular vesicles in disease
- IL-33, ST2, and ILC Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Occupational and environmental lung diseases
- Respiratory viral infections research
- Systemic Sclerosis and Related Diseases
Identifiers and source
- Literature Corpus work
- 2b7d494a-bf1b-5826-bc76-90067b85dca3
- DOI
- 10.1101/2023.12.21.572330