Article

<i>Ex vivo</i> tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

2023-01-16

Abstract excerpt

<h4>ABSTRACT</h4> Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered by the lack of organotypic models and analytical techniques. In this work, we coupled ex vivo cytokine and drug perturbations of human precision-cut lung slices (hPCLS) with scRNAseq and induced a multi-lineage circuit...

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Literature Corpus work: 43bfbc97-61b1-51c5-b926-7a6e88a4b962
DOI: 10.1101/2023.01.16.524219

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