Article

Early Pulmonary Fibrosis is Defined by Niche- and Cell-Specific Molecular Programs

2026-05-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> Preclinical familial pulmonary fibrosis (FPF) represents an early stage of fibrotic lung disease, yet the compartment- and cell-specific molecular programs preceding fibrosis remain poorly understood. <h4>Objective</h4> To define spatially organized molecular signatures associated with preclinical FPF and identify tissue-informed circulating biomarkers linked to early fibrot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e064bbdf-8f43-5937-a53a-8893f8f84d09
DOI: 10.64898/2026.05.28.727955

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Pulmonary Fibrosis is Defined by Niche- and Cell-Specific Molecular ProgramsDOI 10.64898/2026.05.28.727955Read

Spatial transcriptomic characterization of pathologic niches in IPFSemantic proximity Read

Spatial Transcriptomic Characterization of Novel Pathologic Niches in IPFSemantic proximity Read

Alveolar niche disruption and aberrant epithelial reprogramming are early hallmarks of idiopathic pulmonary fibrosisSemantic proximity Read

Resolving the molecular niche of pulmonary fibrosis using cryopreserved human precision cut lung slicesSemantic proximity Read

The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosisSemantic proximity Read

Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosisSemantic proximity Read

Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosisSemantic proximity Read

Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosisSemantic proximity Read

The Identification Markers of activated myofibroblast subsets in the Human Lung Fibrosis Ecosystem via integrated omics AnalysisSemantic proximity Read

Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary FibrosisSemantic proximity Read

Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosisSemantic proximity Read

Translational mapping of spatially resolved transcriptomes in human and mouse pulmonary fibrosisSemantic proximity Read