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Article

Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis

1 Jul 2024

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and limited treatment options. Efforts to identify effective treatments are thwarted by limited understanding of IPF pathogenesis and poor translatability of available preclinical models. Here we generated spatially resolved transcriptome maps of human IPF (n = 4) and bleomycin-induced mouse pulmonary fibrosis (n = 6) to address...

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PMID: 38951642
DOI: 10.1038/s41588-024-01819-2

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