Article

Single-cell transcriptomic assessment of cellular phenotype stability in human precision-cut lung slices

2021-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Precision-cut lung slices (PCLS) are increasingly utilized for ex vivo disease modeling, but a high-resolution characterization of cellular phenotype stability in PCLS has not been reported. Comparing the single-cell transcriptomic profile of human PCLS after five days of culture to freshly isolated human lung tissue, we found striking changes in endothelial cell and alveolar epithelial cell pr...

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Literature Corpus work: 50dbf59f-a54f-5fbd-b640-bae475f38456
DOI: 10.1101/2021.08.19.457016

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