Non-parametric GWAS: Another View on Genome-wide Association Study

Abstract excerpt

Genome-wide association study (GWAS) is a fundamental step for understanding the genetic link to traits (phenotypes) of interest, such as disease, BMI and height. Typically, GWAS estimates the effect of SNP on the phenotype using a linear model by coding SNP as working code, {0, 1, 2}, according to the minor allele frequency. Looking inside the linear model, we find that the coding strategy of SNP plays a key role...

Topics

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• Algorithms
• Case-Control Studies
• Genome-Wide Association Study
• Genomics
• Genotype
• Models, Genetic
• Phenotype
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

af9c8597-19c4-5b45-9ab8-b22114a56e3a

DOI

10.1101/2022.11.11.516099