Article
A two-phase procedure for non-normal quantitative trait genetic association study.
BMC bioinformatics - 28 Jan 2016
Zhang Wei, Li Huiyun, Li Zhaohai, Li Qizhai
Abstract excerpt
BACKGROUND: The nonparametric trend test (NPT) is well suitable for identifying the genetic variants associated with quantitative traits when the trait values do not satisfy the normal distribution assumption. If the genetic model, defined according to the mode of inheritance, is known, the NPT derived under the given genetic model is optimal. However, in practice, the genetic model is often unknown beforehand....
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