Article
Statistical screening method for genetic factors influencing susceptibility to common diseases in a two-stage genome-wide association study.
Statistical applications in genetics and molecular biology - 1 Jan 2009
Sato Yasunori, Laird Nan, Suganami Hideki, Hamada Chikuma, Niki Naoto, Yoshimura Isao, Yoshida Teruhiko
Abstract excerpt
A genome-wide association study (GWAS) is a standard strategy for detecting disease susceptibility genes, despite unsettled controversies on many aspects, including optimal study design and statistical analysis. As for study design, a two-stage design has been applied to maximize cost-effectiveness. However, there has been little consensus on appropriate statistical analysis for two-stage design. Thereby...
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