A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells.

Abstract excerpt

The simultaneous overexpression of several transcription factors has emerged as a successful strategy to convert fibroblasts into other cell types including pluripotent cells, neurons, and cardiomyocytes. The selection and screening of factors are critical, and have often involved testing a large pool of transcription factors, followed by successive removal of single factors. Here, to identify a cardiac...

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