Article

A cardiac fibrosis determinative factor, Meox1, blocks direct reprogramming of cardiac myofibroblasts to cardiomyocyte-like cells

2023-05-22

Abstract excerpt

<title>Abstract</title> <p>Direct reprogramming of cardiac fibroblasts (CFs) into induced cardiomyocyte-like cells (iCMs) is a promising regenerative medicine therapy for myocardial infarction (MI) patients. CFs are activated and transition to myofibroblasts (MFs) after MI, which are abundant in the injured area. However, MFs show lower cardiac reprogramming efficiency. We identified <italic>Meox1</italic>, a TGF...

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Literature Corpus work: c78ec1f0-1a38-5c7a-a16f-f89662ccf998
DOI: 10.21203/rs.3.rs-2928769/v1

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