Article

Oxamniquine resistance alleles are widespread in Old World <i>Schistosoma mansoni</i> and predate drug deployment

2019-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Do mutations required for adaptation occur de novo , or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution of drug resistance. We provide evidence that alleles conferring resistance to oxamniquine (OXA), an antischistosomal drug, are widespread in natur...

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Literature Corpus work: af5889c6-5cdc-53d6-8f84-f2e96015ce54
DOI: 10.1101/657056

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