Article
Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population.
International journal for parasitology - 1 Jun 2016
Chevalier Frédéric D, Le Clec'h Winka, Eng Nina, Rugel Anastasia R, Assis Rafael Ramiro de, Oliveira Guilherme, Holloway Stephen P, Cao Xiaohang, Hart P John, LoVerde Philip T, Anderson Timothy J C
Abstract excerpt
Molecular surveillance provides a powerful approach to monitoring the resistance status of parasite populations in the field and for understanding resistance evolution. Oxamniquine was used to treat Brazilian schistosomiasis patients (mid-1970s to mid-2000s) and several cases of parasite infections resistant to treatment were recorded. The gene underlying resistance (SmSULT-OR) encodes a sulfotransferase required...
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