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Genome-wide analysis of ivermectin response by <i>Onchocerca volvulus</i> reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

2016-12-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several Onchocerca volvulus populations from Cameroon and Ghana - exposed to more than a decade of regular iverm...

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Literature Corpus work: 7408bb63-cd2c-5e3a-8443-bd375a18bd1a
DOI: 10.1101/094540

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