Article
Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.
PLoS pathogens - 1 Oct 2019
Chevalier Frédéric D, Le Clec'h Winka, McDew-White Marina, Menon Vinay, Guzman Meghan A, Holloway Stephen P, Cao Xiaohang, Taylor Alexander B, Kinung'hi Safari, Gouvras Anouk N, Webster Bonnie L, Webster Joanne P, Emery Aidan M, Rollinson David, Garba Djirmay Amadou, Al Mashikhi Khalid M, Al Yafae Salem, Idris Mohamed A, Moné Hélène, Mouahid Gabriel, Hart P John, LoVerde Philip T, Anderson Timothy J C
Abstract excerpt
Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution of drug resistance. We provide evidence that alleles conferring resistance to oxamniquine (OXA), an antischistosomal drug, are widespread in natural parasite...
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