Article

Drug repurposing: halogenated salicylanilides inhibit USP8 catalytic activity and ACTH release by pituitary cells

2025-03-01

Abstract excerpt

Ubiquitin-specific protease 8 (USP8) has emerged as a crucial regulator of various cellular processes including membrane dynamics and receptor trafficking. Additionally, USP8 gain-of-function variants are frequently observed in Cushing’s disease, a severe condition characterized by a pituitary adenoma and dysregulated adrenocorticotropic hormone (ACTH) secretion. Moreover, USP8 overexpression contributes to resist...

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Literature Corpus work: af57697d-b3f9-55c6-87c0-d5ee65a74bdc
DOI: 10.1101/2025.02.26.640120

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