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Article

Targeted analysis of Ubiquitin-Specific Peptidase (USP8) in a population of Iranian people with Cushing's disease and a systematic review of the literature.

BMC endocrine disorders - 11 Jun 2024

Hashemi-Madani Nahid, Cheraghi Sara, Emami Zahra, Mehrjardi Ali Zare, Kaynama Mahmoud Reza, Khamseh Mohammad E

Abstract excerpt

OBJECTIVE: Activating mutation in Ubiquitin-specific peptidase (USP8) is identified to enhance cell proliferation and adrenocorticotropic hormone (ACTH) secretion from corticotroph pituitary adenoma. We investigated the USP8 variant status in a population of Iranian people with functional corticotroph pituitary adenoma (FCPA). Moreover, a systematic review was conducted to thoroughly explore the role of USP8...

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Identifiers

PMID: 38862897
DOI: 10.1186/s12902-024-01619-z
PMCID: PMC11165846

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