Article

High-throughput screening for Cushing’s disease: therapeutic potential of thiostrepton via cell cycle regulation

2024-02-26

Abstract excerpt

Cushing’s disease is a life-threatening disorder caused by autonomous secretion of adrenocorticotropic hormone (ACTH) from pituitary neuroendocrine tumors (PitNETs). Few drugs are indicated for inoperative Cushing’s disease, in particular that due to aggressive PitNETs. To explore agents that regulate ACTH-secreting PitNETs, we conducted high-throughput screening (HTS) using AtT-20, a murine pituitary tumor cell l...

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Literature Corpus work: df1cacf4-6974-5a5e-b3fe-076082f88d9d
DOI: 10.1101/2024.02.22.581351

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