Article
Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutations
2017-05-02
Abstract excerpt
Cushing’s disease is a rare disease with a characteristic phenotype due to significant hypercortisolism driven by over-secretion of adrenocorticotropic hormone and to high morbidity and mortality if untreated. It is caused by a corticotroph adenoma of the pituitary, but the exact mechanisms leading to tumorigenesis are not clear. Recent advances in molecular biology such as the discovery of somatic mutations of th...
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Identifiers and source
- Literature Corpus work
- ed96e578-a25e-5f4f-9fe0-f8d33f302771
- DOI
- 10.12688/f1000research.10968.1